HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results

AIDS Behav. 2016 Sep;20(9):1863-82. doi: 10.1007/s10461-015-1270-0.


Young women in South Africa are at high risk for HIV infection. Cash transfers offer promise to reduce HIV risk. We present the design and baseline results from HPTN 068, a phase III, individually randomized trial to assess the effect of a conditional cash transfer on HIV acquisition among South African young women. A total of 2533 young women were randomized to receive a monthly cash transfer conditional on school attendance or to a control group. A number of individual-, partner-, household- and school-level factors were associated with HIV and HSV-2 infection. After adjusting for age, all levels were associated with an increased odds of HIV infection with partner-level factors conveying the strongest association (aOR 3.05 95 % CI 1.84-5.06). Interventions like cash transfers that address structural factors such as schooling and poverty have the potential to reduce HIV risk in young women in South Africa.

Keywords: Adolescents; Cash transfers; Education; HIV; HIV prevention; South Africa; Young women.

Publication types

  • Clinical Trial, Phase III
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Black People / psychology*
  • Black People / statistics & numerical data
  • Education
  • Female
  • HIV Infections / epidemiology
  • HIV Infections / prevention & control*
  • Herpes Genitalis / epidemiology
  • Herpes Genitalis / prevention & control
  • Humans
  • Incidence
  • Motivation*
  • Outcome Assessment, Health Care
  • Poverty
  • Remuneration*
  • Risk
  • Sexual Partners
  • South Africa / epidemiology
  • Students*