Secretion of islet amyloid polypeptide in response to glucose

FEBS Lett. 1989 Dec 18;259(1):199-201. doi: 10.1016/0014-5793(89)81527-3.

Abstract

The content of islet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse-phase high-performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.

MeSH terms

  • Amyloid / metabolism*
  • Animals
  • Diabetes Mellitus, Type 2 / metabolism
  • Glucose / pharmacology*
  • In Vitro Techniques
  • Islet Amyloid Polypeptide
  • Islets of Langerhans / metabolism*
  • Male
  • Radioimmunoassay
  • Rats
  • Secretory Rate / drug effects

Substances

  • Amyloid
  • Islet Amyloid Polypeptide
  • Glucose