A Peptide Hydrogel Derived From a Fragment of Human Cardiac Troponin C

Chem Commun (Camb). 2016 Mar 14;52(21):4056-9. doi: 10.1039/c6cc00209a.

Abstract

The human cardiac troponin C peptide fragment H-V(9)EQLTEEQKNEFKAAFDIFVLGA(31)-OH, which covers helix-A in the native protein, self-assembles into β-sheet fibrils in solution. These fibrils further entangle to give a hydrogel. This peptide may therefore serve as a template for development of novel biomaterials.

MeSH terms

  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemical synthesis*
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Models, Molecular
  • Peptide Fragments / chemical synthesis*
  • Peptide Fragments / chemistry*
  • Peptides / chemical synthesis*
  • Peptides / chemistry*
  • Protein Structure, Secondary
  • Troponin C / chemistry*
  • X-Ray Diffraction

Substances

  • Peptide Fragments
  • Peptides
  • Troponin C
  • Hydrogel, Polyethylene Glycol Dimethacrylate