Stress granules (SG) and processing bodies (PB) in viral infections

Acta Biochim Pol. 2016;63(2):183-8. doi: 10.18388/abp.2015_1060. Epub 2016 Feb 19.

Abstract

During reaction to stress caused by viral infection, RNA granules are formed in order to protect mRNA. Stress granules (SG) and processing bodies (PB) provide cell homeostasis and mRNA stability. They are formed, for example, during polio virus and MRV (mammalian orthoreovirus) infections. Some viruses, such as influenza virus and HTLV-1 (Human T-lymphotropic virus 1), block the formation of granules. In addition, there are viruses like West Nile Virus, Hepatitis C Virus (HCV) or human Herpes viruses, which influence the functioning of the granules.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoplasmic Granules / physiology*
  • Flaviviridae / physiology
  • Homeostasis
  • Host-Pathogen Interactions
  • Humans
  • Picornaviridae / physiology
  • Protein Biosynthesis
  • Reoviridae / physiology
  • Retroviridae / physiology
  • Virus Diseases / metabolism*
  • Virus Diseases / pathology