Immune Response: Intracellular pathogens under attack

Elife. 2016 Feb 19;5:e14729. doi: 10.7554/eLife.14729.


Antimicrobial proteins deliver a double punch that can destroy the Toxoplasma gondii parasite and its niche inside cells.

Keywords: Förster resonance energy transfer (FRET); biophysics; cell-autonomous immunity; guanylate-binding proteins (GBPs); host-pathogen interaction; immune response; infectious disease; microbiology; mouse; multiparameter fluorescence image spectroscopy (MFIS); structural biology.

Publication types

  • Comment

MeSH terms

  • Cytoplasm / metabolism
  • Humans
  • Interferon-gamma / immunology*
  • Toxoplasma / immunology
  • Vacuoles / immunology*


  • Interferon-gamma