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Comparative Study
. 2016 Nov;30(11):4765-4775.
doi: 10.1007/s00464-016-4804-2. Epub 2016 Feb 19.

Long-term Outcomes of Palliation for Unresectable Colorectal Cancer Obstruction in Patients With Good Performance Status: Endoscopic Stent Versus Surgery

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Comparative Study

Long-term Outcomes of Palliation for Unresectable Colorectal Cancer Obstruction in Patients With Good Performance Status: Endoscopic Stent Versus Surgery

Hyo Jun Ahn et al. Surg Endosc. .

Abstract

Background: In patients with unresectable colorectal cancer (CRC) obstruction, choosing whether to perform self-expandable metal stent (SEMS) or palliative surgery is challenging, especially in those with good performance status. We aimed to compare the long-term outcomes of SEMS with those of palliative surgery in patients with unresectable CRC obstruction.

Methods: This retrospective study comprised 114 patients with unresectable CRC obstruction who underwent SEMS placement (n = 73) or palliative surgery (n = 41). The main outcome measurements were success rate, adverse events, patency, and survival duration.

Results: Early clinical success rates did not differ between SEMS and surgery. However, the rate of late adverse events was significantly higher in the SEMS group (27.4 vs. 9.8 %; P = .005). Patency duration was shorter after SEMS than after surgery (163 vs. 349 days; P < .001), even after additional intervention (202 vs. 349 days; P < .001). The median survival was significantly shorter after SEMS than after surgery (209 vs. 349 days; P = .005). Survival differed between treatments in patients with Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 (P = .016) but not in those with ECOG 2 or 3 (P = .487), and this was confirmed by multivariate analysis, which showed that surgery was a significant favorable predictor of survival for patients with ECOG 0 or 1 (hazard ratio .442; 95 % confidence interval .234-.835; P = .016).

Conclusions: Surgery may be preferable to SEMS for the palliation of unresectable CRC obstruction in patients with good performance status, especially ECOG 0 or 1.

Keywords: Colorectal neoplasm; Malignant obstruction; Metastatic cancer; Palliative surgery; Self-expandable metal stent; Survival.

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