Magnifying Endoscopy Simple Diagnostic Algorithm for Early Gastric Cancer (MESDA-G)

Dig Endosc. 2016 May;28(4):379-393. doi: 10.1111/den.12638. Epub 2016 Apr 22.


Gastric cancer is the third leading cause of cancer death worldwide. Early detection and accurate diagnosis of mucosal cancer is desirable in order to achieve decreased mortality; cause-specific survival of patients with early gastric cancer is reported to exceed 95%. Endoscopy is the functional modality to detect early cancer; however, the procedure is not definitive when using conventional white-light imaging. In contrast, magnifying narrow-band imaging (M-NBI), a novel endoscopic technology, is a powerful tool for characterizing gastric mucosal lesions because it can visualize the microvascular architecture and microsurface structure. To date, many reports on the diagnosis of early gastric cancer by M-NBI, including multicenter prospective randomized studies conducted in Japan, have been published in peer-reviewed international journals. Based on these published data, we devised a proposal for a diagnostic strategy for gastric mucosal cancer using M-NBI to simplify the process of diagnosis and improve accuracy. Herein, we recommend a diagnostic algorithm for early gastric cancer using magnifying endoscopy.

Keywords: diagnosis; early cancer; gastric cancer; magnifying endoscopy; narrow-band imaging.

Publication types

  • Review

MeSH terms

  • Algorithms*
  • Early Detection of Cancer*
  • Gastroscopy
  • Humans
  • Japan
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Stomach Neoplasms / diagnosis*