Infect Dis Clin North Am. 2016 Mar;30(1):179-206. doi: 10.1016/j.idc.2015.10.006.


Cryptococcosis is an invasive mycosis caused by pathogenic encapsulated yeasts in the genus Cryptococcus. Cryptococcus gained prominence as a pathogen capable of widespread disease outbreaks in vulnerable populations. We have gained insight into the pathobiology of Cryptococcus, including the yeast' s capacity to adapt to environmental pressures, exploit new geographic environments, and cause disease in both immunocompromised and apparently immunocompetent hosts. Inexpensive, point-of-care testing makes diagnosis more feasible than ever. The associated worldwide burden and mortality remains unacceptably high. Novel screening strategies and preemptive therapy offer promise at making a sustained and much needed impact on this sugar-coated opportunistic mycosis.

Keywords: Central nervous system (CNS) infection; Cryptococcosis; HIV/AIDS; Immune reconstitution inflammatory syndrome (IRIS); Opportunistic mycoses; Solid organ transplantation (SOT).

Publication types

  • Review

MeSH terms

  • Antifungal Agents / therapeutic use*
  • Cryptococcosis / diagnosis*
  • Cryptococcosis / drug therapy
  • Cryptococcosis / epidemiology
  • Cryptococcosis / immunology
  • Cryptococcus* / genetics
  • Cryptococcus* / pathogenicity
  • Humans


  • Antifungal Agents