UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent

J Calif Dent Assoc. 2016 Jan;44(1):16-28.


The Food and Drug Administration recently cleared silver diamine fluoride for reducing tooth sensitivity. Clinical trials document arrest and prevention of dental caries by silver diamine fluoride. This off-label use is now permissible and appropriate under U.S. law. A CDT code was approved for caries arresting medicaments for 2016 to facilitate documentation and billing. We present a systematic review, clinical indications, clinical protocol and consent procedure to guide application for caries arrest treatment.

MeSH terms

  • Cariostatic Agents / administration & dosage
  • Cariostatic Agents / therapeutic use*
  • Clinical Protocols
  • Dental Caries / prevention & control*
  • Dentin Desensitizing Agents / therapeutic use
  • Fluorides, Topical
  • Humans
  • Off-Label Use / legislation & jurisprudence
  • Quaternary Ammonium Compounds / administration & dosage
  • Quaternary Ammonium Compounds / therapeutic use*
  • San Francisco
  • Silver Compounds
  • Systematic Reviews as Topic
  • Tooth Remineralization / methods
  • United States
  • United States Food and Drug Administration


  • Cariostatic Agents
  • Dentin Desensitizing Agents
  • Fluorides, Topical
  • Quaternary Ammonium Compounds
  • Silver Compounds
  • silver diamine fluoride