The influence of common free radicals and antioxidants on development of Alzheimer's Disease

Biomed Pharmacother. 2016 Mar:78:39-49. doi: 10.1016/j.biopha.2015.12.024. Epub 2016 Jan 11.


Alzheimer's Disease (AD) is one of the most important neurodegenerative disorders in the 21st century for the continually aging population. Despite an increasing number of patients, there are only few drugs to treat the disease. Numerous studies have shown several causes of the disorder, one of the most important being oxidative stress. Oxidative stress is connected with a disturbance between the levels of free radicals and antioxidants in organisms. Solutions to this problem are antioxidants, which counteract the negative impact of the reactive molecules. Unfortunately, the currently available drugs against AD do not exhibit activity toward these structures. Due to the fact that natural substances are extremely significant in new drug development, numerous studies are focused on substances which exhibit a few activities including antioxidants and other anti-AD behaviors. This review article presents the most important studies connected with the influence of free radicals on development of AD and antioxidants as potential drugs toward AD.

Keywords: Alzheimer’s Disease; Natural substances; Oxidative stress; Scavenging of free radicals.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology*
  • Antioxidants / metabolism*
  • Free Radicals / metabolism*
  • Humans
  • Oxidative Stress
  • Reactive Nitrogen Species / metabolism
  • Reactive Oxygen Species / metabolism


  • Antioxidants
  • Free Radicals
  • Reactive Nitrogen Species
  • Reactive Oxygen Species