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Review
. 2016 Mar;78:165-171.
doi: 10.1016/j.biopha.2016.01.014. Epub 2016 Jan 29.

Molecular Regulation of galectin-3 Expression and Therapeutic Implication in Cancer Progression

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Review

Molecular Regulation of galectin-3 Expression and Therapeutic Implication in Cancer Progression

Lei Wang et al. Biomed Pharmacother. .

Abstract

Galectin-3, a multifunctional protein, distributes inside and outside cells and plays an important role in tumor cell adhesion, proliferation, differentiation, angiogenesis, and metastasis in multiple tumors. Changes in galectin-3 expression are commonly seen in cancer and pre-cancerous conditions. Therefore, to understand the molecular regulation of galectin-3 expression could aid the development of new approach for cancer treatment. This review summarizes different expression of galectin-3 in cancer cells and patients' serum, the regulation mechanism and the potential therapeutic targets of galectin-3 in cancer progression.

Keywords: Cancer; Galectin-3; Inflammatory cytokines; Ras/MAPK pathway; Regulation mechanism; Transcription factors.

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