MR imaging in nelarabine-induced myelopathy

J Clin Neurosci. 2016 Jul:29:205-6. doi: 10.1016/j.jocn.2015.12.014. Epub 2016 Feb 16.


Nelarabine is one of the newer and novel drugs approved by the USA Food and Drug Administration for treatment of relapsed and resistant acute lymphoblastic leukemia. Although there are a few accounts of the neurologic toxicity of nelarabine in the oncological literature, it has never been discussed from a radiologic stand point to our knowledge. We describe a case of nelarabine-induced myelopathy and review the existing literature in an attempt to characterize the MRI features helpful in making an early diagnosis of this elusive entity.

Keywords: Dorsal column; Myelopathy; Nelarabine; Neurotoxicity; Spinal cord.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects*
  • Arabinonucleosides / adverse effects*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Neuroimaging / methods
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Spinal Cord Diseases / chemically induced*
  • Spinal Cord Diseases / diagnostic imaging*
  • United States


  • Antineoplastic Agents
  • Arabinonucleosides
  • nelarabine