Biomedical Potential of mTOR Modulation by Nanoparticles

Abstract

Modulation of the mammalian target of rapamycin (mTOR), the principal regulator of cellular homeostasis, underlies the biological effects of engineered nanoparticles, including regulation of cell death/survival and metabolic responses. Understanding the mechanisms and biological actions of nanoparticle-mediated mTOR modulation may help in developing safe and efficient nanotherapeutics to fight human disease.

Keywords: autophagy; cancer; cell death; mTOR; nanoparticles; oxidative stress.