Lattice engineering through nanoparticle-DNA frameworks

Nat Mater. 2016 Jun;15(6):654-61. doi: 10.1038/nmat4571. Epub 2016 Feb 22.


Advances in self-assembly over the past decade have demonstrated that nano- and microscale particles can be organized into a large diversity of ordered three-dimensional (3D) lattices. However, the ability to generate different desired lattice types from the same set of particles remains challenging. Here, we show that nanoparticles can be assembled into crystalline and open 3D frameworks by connecting them through designed DNA-based polyhedral frames. The geometrical shapes of the frames, combined with the DNA-assisted binding properties of their vertices, facilitate the well-defined topological connections between particles in accordance with frame geometry. With this strategy, different crystallographic lattices using the same particles can be assembled by introduction of the corresponding DNA polyhedral frames. This approach should facilitate the rational assembly of nanoscale lattices through the design of the unit cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacteriophage M13 / chemistry*
  • Bacteriophage M13 / genetics
  • DNA, Viral / chemistry*
  • DNA, Viral / genetics
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry*


  • DNA, Viral
  • Gold