Evaluation of an enhanced recovery protocol after pancreaticoduodenectomy in elderly patients

HPB (Oxford). 2016 Feb;18(2):153-158. doi: 10.1016/j.hpb.2015.09.009. Epub 2015 Dec 10.


Background: Recent evidence has shown that enhanced recovery after surgery (ERAS) protocols decrease hospital stay following pancreaticoduodenectomy (PD). The aims of this study were to assess the feasibility and to evaluate the effect of introducing ERAS principles after PD in elderly patients.

Methods: Patients ≥75 years were defined as elderly. Comparison of postoperative outcome was performed between 22 elderly patients who underwent ERAS (elderly ERAS + patients) and a historical cohort of 66 elderly patients who underwent standard protocols (elderly ERAS-patients).

Results: The lowest adherence with ERAS among elderly patients was observed for starting a solid food diet within POD 4 (n = 7) and early drains removal (n = 2). The highest adherence was observed for post-operative glycemic control (n = 21), epidural analgesia (n = 21), mobilization (n = 20) and naso-gastric removal in POD 0 (n = 20). Post-operative outcomes did not differ between elderly ERAS+ and elderly ERAS- patients. In patients with an uneventful postoperative course, the median intention to discharge was earlier in elderly ERAS + patients as compared to the elderly ERAS- patients (4 days versus 8 days, P < 0.001).

Conclusion: An ERAS protocol following PD seems to be feasible and safe among elderly although it is not associated with improved postoperative outcomes.

Publication types

  • Observational Study

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Female
  • Guideline Adherence
  • Historically Controlled Study
  • Humans
  • Length of Stay
  • Male
  • Pancreaticoduodenectomy / adverse effects
  • Pancreaticoduodenectomy / rehabilitation*
  • Pancreaticoduodenectomy / standards
  • Patient Discharge
  • Postoperative Care / adverse effects
  • Postoperative Care / methods*
  • Postoperative Care / standards
  • Postoperative Complications / etiology
  • Postoperative Complications / therapy
  • Practice Guidelines as Topic
  • Recovery of Function
  • Retrospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome