Regulation of FGF signaling: Recent insights from studying positive and negative modulators

Lina Korsensky; Dina Ron

doi:10.1016/j.semcdb.2016.01.023

Regulation of FGF signaling: Recent insights from studying positive and negative modulators

Semin Cell Dev Biol. 2016 May:53:101-14. doi: 10.1016/j.semcdb.2016.01.023. Epub 2016 Feb 20.

Authors

Lina Korsensky¹, Dina Ron²

Affiliations

¹ Department of Biology, Technion, Israel Institute of Technology, Haifa 3200003, Israel.
² Department of Biology, Technion, Israel Institute of Technology, Haifa 3200003, Israel. Electronic address: dinar@tx.technion.ac.il.

PMID: 26903404
DOI: 10.1016/j.semcdb.2016.01.023

Abstract

Fibroblast growth factor (FGF) signaling is involved in a multitude of biological processes, while impairment of FGF signaling is implicated in a variety of human diseases including developmental disorders and cancer. Therefore, it is not surprising that FGF activity is regulated at multiple and distinct levels. This review focuses on positive and negative modulation of the FGF signal exemplified by recently identified protein modulators anosmin-1, fibronectin-leucine-rich transmembrane protein 3 (FLRT3) and similar expression to FGF (Sef). We examine how these proteins regulate FGF signaling at multiple levels and across species. Finally, we describe the role of these regulators in human disease.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Embryonic Development
Fibroblast Growth Factors / chemistry
Fibroblast Growth Factors / metabolism*
Humans
Models, Animal
Models, Biological
Neoplasms / metabolism
Signal Transduction*

Substances

Fibroblast Growth Factors