Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

Chem Commun (Camb). 2016 Mar 18;52(22):4187-90. doi: 10.1039/c6cc00615a.

Abstract

3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Aminopyridine / administration & dosage
  • 4-Aminopyridine / analogs & derivatives*
  • 4-Aminopyridine / pharmacokinetics
  • Administration, Oral
  • Amifampridine
  • Botulinum Toxins, Type A / poisoning*
  • Capsules*
  • Lycopodium / chemistry*
  • Microscopy, Electron, Scanning

Substances

  • Capsules
  • 4-Aminopyridine
  • Botulinum Toxins, Type A
  • Amifampridine