Enabling direct fate conversion with network biology

Nat Genet. 2016 Mar;48(3):226-7. doi: 10.1038/ng.3516.


Current efforts in cellular disease modeling and regenerative medicine are limited by the paucity of cell types that can be generated in the laboratory. A new study introduces a computational framework, Mogrify, that uses network biology to predict combinations of transcription factors necessary for direct conversion between human cell types to ameliorate this issue.

Publication types

  • News
  • Comment

MeSH terms

  • Cell Differentiation / genetics*
  • Cell Transdifferentiation / genetics*
  • Cellular Reprogramming / genetics*
  • Gene Regulatory Networks*
  • Humans