Pluripotent stem cells progressing to the clinic

Nat Rev Mol Cell Biol. 2016 Mar;17(3):194-200. doi: 10.1038/nrm.2016.10.


Basic experimental stem cell research has opened up the possibility of many diverse clinical applications; however, translation to clinical trials has been restricted to only a few diseases. To broaden this clinical scope, pluripotent stem cell derivatives provide a uniquely scalable source of functional differentiated cells that can potentially repair damaged or diseased tissues to treat a wide spectrum of diseases and injuries. However, gathering sound data on their distribution, longevity, function and mechanisms of action in host tissues is imperative to realizing their clinical benefit. The large-scale availability of treatments involving pluripotent stem cells remains some years away, because of the long and demanding regulatory pathway that is needed to ensure their safety.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell- and Tissue-Based Therapy / methods*
  • Humans
  • Induced Pluripotent Stem Cells*
  • Stem Cell Transplantation*