Streamlining Screening to Treatment: The Hepatitis C Cascade of Care at Kaiser Permanente Mid-Atlantic States

Clin Infect Dis. 2016 May 15;62(10):1290-1296. doi: 10.1093/cid/ciw086. Epub 2016 Feb 16.


Hepatitis C virus (HCV) screening is recommended for patients at risk and/or born during 1945-1965, but screening gaps persist. This new program screens target populations and enhances care linkage for chronically HCV-infected patients. Kaiser Permanente Mid-Atlantic States created a comprehensive HCV screening pathway, supported by a HCV care coordinator. The testing pathway includes HCV antibody (Ab), automatic HCV RNA for Ab-positive patients, coinfection and liver health tests, vibration-controlled transient elastography (VCTE), and a physician referral. A total of 11 200 patients were screened; 3.25% were HCV Ab positive, and 100% of Ab-positive patients received HCV RNA testing. Of HCV Ab-positive patients, 75.9% had chronic HCV, of which 80.8% underwent VCTE. HCV diagnosis was communicated to 94% of patients, and 70.9% had HCV documented in the electronic health record. The pathway shows promise in closing gaps, including improving HCV RNA testing, communicating diagnoses, and assessing liver fibrosis. Improved testing and linkage could increase curative treatment access.

Keywords: HCV; cascade of care; hepatitis C virus; linkage to care; screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cohort Studies
  • Female
  • Hepacivirus / genetics*
  • Hepacivirus / immunology*
  • Hepatitis C / diagnosis*
  • Hepatitis C / immunology
  • Hepatitis C / virology
  • Hepatitis C Antibodies / blood
  • Humans
  • Liver Cirrhosis / diagnostic imaging
  • Male
  • Mass Screening / methods*
  • Mid-Atlantic Region
  • Middle Aged


  • Hepatitis C Antibodies