Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density

J Acquir Immune Defic Syndr. 2016 Jul 1;72(3):314-8. doi: 10.1097/QAI.0000000000000965.


Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / adverse effects
  • Bone Density
  • Cross-Sectional Studies
  • Female
  • Femur Neck / pathology*
  • Femur Neck / virology
  • HIV Infections / complications*
  • HIV Infections / pathology
  • HIV Infections / virology
  • Humans
  • Lumbar Vertebrae / pathology*
  • Lumbar Vertebrae / virology
  • Male
  • Middle Aged
  • Osteoporosis / pathology*
  • Osteoporosis / virology
  • Risk Assessment
  • Spain


  • Anti-HIV Agents