Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation

Jacob Haugen; Martijn L T M Müller; Vikas Kotagal; Roger L Albin; Robert A Koeppe; Peter J H Scott; Kirk A Frey; Nicolaas I Bohnen

doi:10.1007/s00702-016-1524-7

Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation

J Neural Transm (Vienna). 2016 Apr;123(4):421-4. doi: 10.1007/s00702-016-1524-7. Epub 2016 Feb 24.

Authors

Jacob Haugen¹, Martijn L T M Müller^{1

2}, Vikas Kotagal^{3

4}, Roger L Albin^{3

2

4}, Robert A Koeppe¹, Peter J H Scott¹, Kirk A Frey^{1

3}, Nicolaas I Bohnen^{5

6

7

8}

Affiliations

¹ Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA.
² University of Michigan Morris K. Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA.
³ Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
⁴ Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA.
⁵ Functional Neuroimaging, Cognitive and Mobility Laboratory, Department of Radiology, University of Michigan, 24 Frank Lloyd Wright Drive, Box 362, Ann Arbor, MI, 48105-9755, USA. nbohnen@umich.edu.
⁶ Department of Neurology, University of Michigan, Ann Arbor, MI, USA. nbohnen@umich.edu.
⁷ University of Michigan Morris K. Udall Center of Excellence for Parkinson's Disease Research, Ann Arbor, MI, USA. nbohnen@umich.edu.
⁸ Neurology Service and GRECC, VAAAHS, Ann Arbor, MI, USA. nbohnen@umich.edu.

Abstract

There is wide variability in the reported prevalence rates of abnormal smell in Parkinson disease (PD). This study assessed the prevalence of abnormal smell, using the University of Pennsylvania Smell Identification Test (UPSIT), in 183 patients with PD with confirmed PET imaging evidence of nigrostriatal denervation. Impaired olfaction in this sample was nearly universal (97.8 %). Wide-ranging prior olfactory impairment estimates may reflect not only uncertainty regarding diagnostic classification, but also the use of inaccurate normative data and differences in olfactory tests used.

Keywords: Aging; Dopamine; Olfaction; PET; Parkinson disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Olfaction Disorders / epidemiology*
Olfaction Disorders / etiology
Parkinson Disease / complications*
Parkinson Disease / pathology*
Positron-Emission Tomography
Prevalence
Substantia Nigra / pathology*

Abstract

Publication types

MeSH terms

Grants and funding