STAMPing at the crossroads of normal physiology and disease states

Mol Cell Endocrinol. 2016 Apr 15;425:26-36. doi: 10.1016/j.mce.2016.02.013. Epub 2016 Feb 18.

Abstract

The six transmembrane protein of prostate (STAMP) proteins, also known as six transmembrane epithelial antigen of prostate (STEAPs), comprises three members: STAMP1-3. Their expression is regulated by a variety of stimuli, including hormones and cytokines, in varied settings and tissues with important roles in secretion and cell differentiation. In addition, they are implicated in metabolic and inflammatory diseases and cancer. Here, we review the current knowledge on the role of STAMPs in both physiological and pathological states.

Keywords: Inflammation; Ironreductase; Metabolism; Prostate cancer; STAMP; STEAP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins
  • Cell Differentiation
  • Gene Expression Regulation
  • Humans
  • Inflammation / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Metabolic Diseases / metabolism
  • Neoplasm Proteins / chemistry
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms / metabolism
  • Oncogene Proteins / chemistry
  • Oncogene Proteins / genetics
  • Oncogene Proteins / metabolism*
  • Oxidoreductases / chemistry
  • Oxidoreductases / genetics
  • Oxidoreductases / metabolism*
  • Tissue Distribution

Substances

  • Cell Cycle Proteins
  • Membrane Proteins
  • Neoplasm Proteins
  • Oncogene Proteins
  • Oxidoreductases
  • STEAP3 protein, human
  • STEAP2 protein, human
  • STEAP4 protein, human