Uncommon Tumor, Uncommon Location: A Dermal-Based Spindle Cell/Pleomorphic Lipoma

Am J Dermatopathol. 2016 Aug;38(8):e122-4. doi: 10.1097/DAD.0000000000000546.


Spindle cell/pleomorphic lipoma is an uncommonly encountered benign neoplasm that is usually found in the subcutaneous tissues. Rare cases reported in the literature have an intradermal location. This lesion usually presents as a subcutaneous nodule on the neck, shoulders, or back of middle-aged to elderly males. Although spindle cell and pleomorphic lipoma are currently considered the same entity, they were historically categorized separately. The authors report a case of hyperpigmented papule with an associated subcutaneous nodule on the left cheek of a 56-year-old man, review the literature, and discuss several important diagnostic pitfalls of spindle cell/pleomorphic lipoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biopsy
  • Cheek
  • Diagnosis, Differential
  • Humans
  • Hyperpigmentation / pathology*
  • Immunohistochemistry
  • Lipoma / chemistry
  • Lipoma / pathology*
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / pathology*
  • Skin Pigmentation*


  • Biomarkers, Tumor