Canadian Consensus Guidelines on Use of Amyloid Imaging in Canada: Update and Future Directions from the Specialized Task Force on Amyloid imaging in Canada

Can J Neurol Sci. 2016 Jul;43(4):503-12. doi: 10.1017/cjn.2015.401. Epub 2016 Feb 26.


Positron emission tomography (PET) imaging of brain amyloid beta is now clinically available in several countries including the United States and the United Kingdom, but not Canada. It has become an established technique in the field of neuroimaging of aging and dementia, with data incorporated in the new consensus guidelines for the diagnosis of Alzheimer disease and predementia Alzheimer's disease-related conditions. At this point, there are three US Food and Drug Administration- and European Union-approved tracers. Guided by appropriate use criteria developed in 2013 by the Alzheimer's Association and the Society of Nuclear Medicine and Molecular Imaging, the utility of amyloid imaging in medical practice is now supported by a growing body of research. In this paper, we aimed to provide an update on the 2012 Canadian consensus guidelines to dementia care practitioners on proper use of amyloid imaging. We also wished to generate momentum for the industry to submit a new drug proposal to Health Canada. A group of local, national, and international dementia experts and imaging specialists met to discuss scenarios in which amyloid PET could be used appropriately. Peer-reviewed and published literature between January 2004 and May 2015 was searched. Technical and regulatory considerations pertaining to Canada were considered. The results of a survey of current practices in Canadian dementia centers were considered. A set of specific clinical and research guidelines was agreed on that defines the types of patients and clinical circumstances in which amyloid PET could be used in Canada. Future research directions were also outlined, notably the importance of studies that would assess the pharmaco-economics of amyloid imaging.

Keywords: Alzheimer’s Disease; Amyloid imaging; Atypical Dementia; Biomarkers; Consensus Guidelines; MCI; PET.

MeSH terms

  • Alzheimer Disease / cerebrospinal fluid
  • Alzheimer Disease / diagnostic imaging*
  • Amyloid / metabolism*
  • Amyloid beta-Peptides / cerebrospinal fluid
  • Canada
  • Consensus*
  • Databases, Bibliographic / statistics & numerical data
  • Guidelines as Topic / standards*
  • Humans
  • Magnetic Resonance Imaging
  • Multicenter Studies as Topic
  • Peptide Fragments / cerebrospinal fluid
  • Positron-Emission Tomography / methods*
  • Positron-Emission Tomography / standards*


  • Amyloid
  • Amyloid beta-Peptides
  • Peptide Fragments
  • amyloid beta-protein (1-42)