Acute Pulmonary Embolism: With an Emphasis on an Interventional Approach

J Am Coll Cardiol. 2016 Mar 1;67(8):991-1002. doi: 10.1016/j.jacc.2015.12.024.


Compared with recent advances in treatment of serious cardiovascular diseases, such as myocardial infarction and stroke, the treatment and outcome of acute pulmonary embolism (PE) have remained relatively unchanged over the last few decades. This has prompted several experts to call for the formation of multidisciplinary PE response teams with a more proactive approach to the treatment of PE. In the current document, we discuss the formation of such teams and describe the available treatment options beyond anticoagulation, with a focus on the interventional approach. Acknowledging the paucity of data to support widespread adoption of such techniques, we call for the collection of outcomes data in multicenter registries and support for randomized trials to evaluate interventional treatments in patients with high-risk PE.

Keywords: embolectomy; fibrinolysis; interventional management; pulmonary artery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Anticoagulants / therapeutic use*
  • Disease Management*
  • Embolectomy / methods*
  • Humans
  • Pulmonary Embolism / therapy*
  • Registries*
  • Thrombolytic Therapy / methods*


  • Anticoagulants