Impact of Type and Duration of Application of Commercially Available Oral Moisturizers on Their Antifungal Effects

J Prosthodont. 2018 Jan;27(1):52-56. doi: 10.1111/jopr.12458. Epub 2016 Feb 24.


Purpose: To examine the impact of oral moisturizer type and application time on antifungal effects.

Materials and methods: Seventeen oral moisturizers (7 liquids, 10 gels) and amphotericin B (AMPH-B) were tested. Antifungal effects were evaluated with newly opened moisturizer samples (0 hour) and with samples incubated for 8 hours to simulate contact during sleep. Candida albicans samples (108 cells/ml) were placed into cylindrical holes in 50% trypticase soy agar plates. Antifungal effects were evaluated based on growth-inhibitory zones after 24 hours. Equal quantities of moisturizers showing growth-inhibitory zones were mixed as additional samples. The effects of moisturizer type and application time on growth-inhibitory zones were evaluated with ANOVA. Growth-inhibitory zone sizes were compared with multiple comparisons.

Results: Growth-inhibitory zones were found with two liquids, one gel, moisturizer mixtures, and AMPH-B. Significant differences in antifungal effects were found among different moisturizer types and between the 0- and 8-hour groups. The growth-inhibitory zones of the 8-hour group were significantly smaller than those of the 0-hour group. In both the 0- and 8-hour groups, the growth-inhibitory zones of the liquid-gel mixtures were significantly larger than those of other moisturizer types, and were the same size as those of AMPH-B at two concentrations (1.25 and 2.5 μg/ml). Growth-inhibitory zones of individual moisturizers and liquid-liquid mixtures were the same size as those of lower AMPH-B concentrations (0.16, 0.31, and 0.63 μg/ml).

Conclusion: Our findings suggest that mixing liquid and gel moisturizers improves their antifungal efficiency.

Keywords: Candida albicans; Oral moisturizers; dry mouth; oral candidiasis.

MeSH terms

  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Emollients / chemistry*
  • Humans
  • Time Factors
  • Xerostomia / therapy


  • Antifungal Agents
  • Emollients