Considerations for the analysis of longitudinal electronic health records linked to claims data to study the effectiveness and safety of drugs

Clin Pharmacol Ther. 2016 Aug;100(2):147-59. doi: 10.1002/cpt.359. Epub 2016 May 12.


Health insurance claims and electronic health records (EHR) databases have been considered the preferred data sources with which to study drug safety and effectiveness in routine care. Linking claims data to EHR allows researchers to leverage the complementary advantages of each data source to enhance study validity. We propose a framework to evaluate the need for supplementing claims data with EHR and vice versa to optimize outcome ascertainment, exposure assessment, and confounding adjustment.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adverse Drug Reaction Reporting Systems / statistics & numerical data
  • Databases, Factual / statistics & numerical data*
  • Drug-Related Side Effects and Adverse Reactions / epidemiology
  • Electronic Health Records / statistics & numerical data*
  • Humans
  • Insurance, Health / statistics & numerical data
  • Medical Record Linkage / methods*
  • Pharmaceutical Preparations / administration & dosage


  • Pharmaceutical Preparations