Barriers and Challenges in Hyperemesis Gravidarum Research

Nutr Metab Insights. 2016 Feb 14;8(Suppl 1):33-9. doi: 10.4137/NMI.S29523. eCollection 2015.


Nausea and occasional vomiting in early pregnancy (NVP) are common. When vomiting is severe or protracted, it is referred to as hyperemesis gravidarum (HG). HG affects up to 3% of pregnancies and is characterized by weight loss, dehydration, electrolyte imbalance, and the need for hospital admission. HG has significant consequences for maternal well-being, is associated with adverse birth outcomes, and leads to major health care costs. Treatment options are symptomatic, hampered by the lack of evidence-based options including studies on nutritional interventions. One of the reasons for this lack of evidence is the use of a broad range of definitions and outcome measures. An internationally accepted definition and the formulation of core outcomes would facilitate meta-analysis of trial results and implementation of evidence in guidelines to ultimately improve patient care.

Keywords: consensus; consequences; definition; hyperemesis gravidarum; outcomes; treatment.

Publication types

  • Review