Antifungal, anti-oomycete and phytotoxic effects of volatile organic compounds from the endophytic fungus Xylaria sp. strain PB3f3 isolated from Haematoxylon brasiletto

J Appl Microbiol. 2016 May;120(5):1313-25. doi: 10.1111/jam.13101. Epub 2016 Apr 4.

Abstract

Aims: To determine the antifungal, anti-oomycete and phytotoxic activity; and chemical composition of the volatile organic compounds (VOCs) produced by endophytic fungus Xylaria sp. PB3f3 isolated from Haematoxylon brasiletto Karst.

Methods and results: Bioactivity and chemical composition of the VOCs from Xylaria sp. PB3f3 were established by using simple and multiple antagonism bioassays, and gas chromatography/mass spectrometry, respectively. The results showed that Xylaria sp. PB3f3 inhibited the growth of the oomycetes Pythium aphanidermatum (78·3%), Phytophthora capsici (48·3%), and the fungi Alternaria solani (24·5%) and Fusarium oxysporum (24·2%), in multiple antagonism bioassays. Volatile organic compounds, produced at 20 and 30 days of fungal growth, inhibited root elongation on Amaranthus hypochondriacus (27·6%) and on Solanum lycopersicum (53·2%). Forty VOCs were identified at 10, 20 and 30 days in Xylaria sp. PB3f3 cultures. The compounds with the highest fibre affinity were: 3-methyl-1-butanol and thujopsene, at 10 days of fungal growth; an unidentified amine and 2-methyl-1-butanol at 20 days; and 2-methyl-1-propanol at 30 days. In the gas phase assay method 2-methyl-1-propanol and 2-methyl-1-butanol showed significant inhibitory effects on root elongation and germination of Am. hypochondriacus and S. lycopersicum.

Conclusions: Xylaria sp. PB3f3 and its VOCs showed significant phytotoxic effects on root elongation and germination of Am. hypochondriacus and S. lycopersicum.

Significance and impact of the study: The genus Xylaria produces a great variety of secondary metabolites, but, up date, there are no reports of the identification of bioactive volatile compounds. Thus, Xylaria sp. PB3f3 and its VOCs are a possible candidate for the biological control of weeds.

Keywords: Xylaria sp; biological control; endophytic fungus; solid phase microextraction; volatile metabolites; weed control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternaria / drug effects
  • Alternaria / growth & development
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / metabolism
  • Antifungal Agents / pharmacology*
  • Fabaceae / microbiology*
  • Fusarium / drug effects
  • Fusarium / growth & development
  • Gas Chromatography-Mass Spectrometry
  • Microbial Sensitivity Tests
  • Oomycetes / drug effects
  • Oomycetes / growth & development
  • Plant Roots / metabolism
  • Volatile Organic Compounds / isolation & purification
  • Volatile Organic Compounds / metabolism
  • Volatile Organic Compounds / pharmacology*
  • Xylariales / metabolism*

Substances

  • Antifungal Agents
  • Volatile Organic Compounds

Associated data

  • GENBANK/AB524023
  • GENBANK/AB54023
  • GENBANK/AF163030
  • GENBANK/EF423534
  • GENBANK/FJ707473
  • GENBANK/GU324746
  • GENBANK/GU324747
  • GENBANK/H435669
  • GENBANK/JN225908
  • GENBANK/JQ623492
  • GENBANK/JQ936297
  • GENBANK/JX160062
  • GENBANK/KC771495
  • GENBANK/KP400260