Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells

Vet J. 2016 Apr:210:85-8. doi: 10.1016/j.tvjl.2015.12.008. Epub 2015 Dec 29.

Abstract

Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.

Keywords: Down-regulation; Equine herpesvirus 1; Monocyte-derived dendritic cells; pUL56.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Differentiation / immunology
  • Antigens, Differentiation / metabolism*
  • Cells, Cultured
  • Dendritic Cells / immunology*
  • Down-Regulation
  • Female
  • Herpesviridae Infections / immunology
  • Herpesviridae Infections / veterinary
  • Herpesvirus 1, Equid / immunology*
  • Horses
  • Immunophenotyping
  • Male

Substances

  • Antigens, Differentiation