New cytotoxic neo-clerodane diterpenoids from Scutellaria strigillosa

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1750-3. doi: 10.1016/j.bmcl.2016.02.045. Epub 2016 Feb 17.

Abstract

Three new neo-clerodane diterpenoids, named scutestrigillosins A-C (1-3), were isolated from the whole plant of Scutellaria strigillosa. Their chemical structures including absolute configurations were established on the basis of detailed physical data analyses. In vitro, the isolated three new compounds exhibited significant cytotoxic activities against four tumor cell lines (HONE-1, P-388, MCF7 and HT29), and gave IC50 values in the range 3.5-7.7μM.

Keywords: Cytotoxic activity; Scutellaria strigillosa; Scutestrigillosins A–C; neo-Clerodane diterpenoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Diterpenes, Clerodane / chemistry*
  • Diterpenes, Clerodane / isolation & purification
  • Diterpenes, Clerodane / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Neoplasms / drug therapy
  • Scutellaria / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes, Clerodane