The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

J Microbiol. 2016 Mar;54(3):243-53. doi: 10.1007/s12275-016-5510-4. Epub 2016 Feb 27.


Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies.

Keywords: aspergillosis; cell wall stress; fungicide resistance; heat shock; hypoxia; osmotic stress; oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Biological
  • Animals
  • Antifungal Agents / pharmacology*
  • Aspergillosis / drug therapy
  • Aspergillus fumigatus / drug effects
  • Aspergillus fumigatus / metabolism
  • Aspergillus fumigatus / physiology*
  • Drug Resistance, Fungal
  • Host-Pathogen Interactions
  • Humans
  • Stress, Physiological / physiology*
  • Virulence / drug effects


  • Antifungal Agents