Reactivity between monoclonal anti-HLA-B27 antibodies and bacterial components: is there a consensus of findings?

Rheumatol Int. 1989;9(3-5):219-21. doi: 10.1007/BF00271884.


Studies addressing the molecular aspects of the postulated cross-reactivity between the HLA-B27 antigens and the bacteria known to precipitate arthritis (e.g., Shigella, Salmonella, Yersinia and Campylobacter) are reviewed. In conclusion, the necessity for further research into the pathogenesis of arthritis is stressed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Antibodies, Monoclonal / immunology*
  • Arthritis, Infectious / immunology
  • Bacterial Outer Membrane Proteins / immunology*
  • Cross Reactions / immunology*
  • Enterobacteriaceae / immunology
  • HLA-B27 Antigen / immunology*
  • Humans
  • Molecular Sequence Data


  • Antibodies, Monoclonal
  • Bacterial Outer Membrane Proteins
  • HLA-B27 Antigen