The Need for Speed-Kinetic Limits of Drug Transporters

Trends Pharmacol Sci. 2016 Apr;37(4):243-245. doi: 10.1016/j.tips.2016.02.002. Epub 2016 Feb 24.

¹ Department of Pharmacy, Uppsala University, Box 580, 751 23 Uppsala, Sweden; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) - a node of the Chemical Biology Consortium Sweden, Uppsala, Sweden. Electronic address: par.matsson@farmaci.uu.se.
² Department of Pharmacy, Uppsala University, Box 580, 751 23 Uppsala, Sweden.
³ Department of Pharmacy, Uppsala University, Box 580, 751 23 Uppsala, Sweden; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) - a node of the Chemical Biology Consortium Sweden, Uppsala, Sweden; Science for Life Laboratory Drug Discovery and Development Platform, Uppsala University, Uppsala, Sweden. Electronic address: per.artursson@farmaci.uu.se.

No abstract available

Keywords: carrier-mediated transport; drug transport; passive diffusion; permeability; systems biology; transporter.

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