Genetic Polymorphism of GABRR2 Modulates Individuals' General Cognitive Ability in Healthy Chinese Han People

Cell Mol Neurobiol. 2017 Jan;37(1):93-100. doi: 10.1007/s10571-016-0347-2. Epub 2016 Feb 27.

Abstract

Previous studies have indicated that the cognitive impairment or deficit is associated with GABAergic signaling in central nervous system. Inspired by the finding that receptor GABRR2 modulates concentration of GABA and phasic inhibitory GABAergic transmission in brain. This study investigated to what extent a genetic variant (c.1423C>T, rs282129) of GABRR2 gene modulates individuals' general cognitive ability in 987 Chinese Han people. Results showed a significant influence of GABRR2 gene polymorphism on individuals' Raven's Standard Progressive Matrices (RSPM) performance (F = 3.58, P = .028 by ANOVA and χ 2 = 9.35, P = .009 by K-W test, respectively), even if non-genetic factors were partialed out (gender, major, types of birthplace, and socioeconomic index) (B = -.67, SE = .26, t = 2.63, P = .009). The finding provided a strong evidence, to our knowledge, for the view that genetic variant of GABRR2 gene may contribute to the difference of individuals' general cognitive ability, independently.

Keywords: Gamma-aminobutyric acid (GABA); General cognitive ability; Genetic variants; Raven’s Standard Progressive Matrices (RSPM).

MeSH terms

  • Adolescent
  • Asians / genetics*
  • Cognition / physiology*
  • Cognition Disorders / epidemiology
  • Cognition Disorders / genetics*
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genetic Variation / genetics
  • Humans
  • Male
  • Polymorphism, Genetic / genetics*
  • Receptors, GABA-A / genetics*
  • Young Adult

Substances

  • GABRR2 protein, human
  • Receptors, GABA-A