Multilevel regulation of Streptomyces differentiation

Trends Genet. 1989 Nov;5(11):372-7. doi: 10.1016/0168-9525(89)90172-8.


Streptomyces species are unusual among bacteria in their extensive colony differentiation, which involves the development of spore-bearing aerial hyphae on mycelial colonies. This process, which is usually accompanied by antibiotic production, is controlled by factors as diverse as pheromones, a transfer RNA and a sigma factor dedicated to differentiation, and perhaps by storage compounds and substances related to antibiotics.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Anti-Bacterial Agents / biosynthesis
  • Molecular Sequence Data
  • Pheromones / pharmacology
  • RNA, Transfer / physiology*
  • Spores, Bacterial
  • Streptomyces / drug effects
  • Streptomyces / genetics*
  • Streptomyces / growth & development


  • Anti-Bacterial Agents
  • Pheromones
  • RNA, Transfer