HIV-Host Interactions: Implications for Vaccine Design

Cell Host Microbe. 2016 Mar 9;19(3):292-303. doi: 10.1016/j.chom.2016.02.002. Epub 2016 Feb 25.


Development of an effective AIDS vaccine is a global priority. However, the extreme diversity of HIV type 1 (HIV-1), which is a consequence of its propensity to mutate to escape immune responses, along with host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine development. Breakthroughs in understanding of the biology of the transmitted virus, the structure and nature of its envelope trimer, vaccine-induced CD8 T cell control in primates, and host control of broadly neutralizing antibody elicitation have given rise to new vaccine strategies. Despite this promise, emerging data from preclinical trials reinforce the need for additional insight into virus-host biology in order to facilitate the development of a successful vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS Vaccines / immunology*
  • AIDS Vaccines / isolation & purification
  • Animals
  • Antibodies, Neutralizing / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Drug Discovery / methods
  • Drug Discovery / trends
  • Drug Evaluation, Preclinical
  • HIV Antibodies / immunology
  • HIV-1 / immunology*
  • HIV-1 / pathogenicity*
  • Host-Pathogen Interactions*
  • Primates
  • Treatment Outcome


  • AIDS Vaccines
  • Antibodies, Neutralizing
  • HIV Antibodies