Decoding the RNA structurome

Curr Opin Struct Biol. 2016 Feb:36:142-8. doi: 10.1016/j.sbi.2016.01.007. Epub 2016 Feb 26.

Abstract

Structures of RNA molecules are essential for their architectural, regulatory, and catalytic functions. Recent advances in high throughput sequencing enabled the development of methods for probing RNA structures on a transcriptome-wide scale-termed the RNA structurome. Here we review the state-of-the-art technologies for probing the RNA structurome, and highlight insights gained from these studies. We also point out the limits of current methods and discuss potential directions for future improvements.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Computational Biology / methods
  • Nucleic Acid Conformation*
  • RNA / chemistry*
  • RNA / genetics
  • Structure-Activity Relationship
  • Transcriptome

Substances

  • RNA