Current research in necrotizing enterocolitis

Simon Eaton; Clare M Rees; Nigel J Hall

doi:10.1016/j.earlhumdev.2016.01.013

Current research in necrotizing enterocolitis

Early Hum Dev. 2016 Jun:97:33-9. doi: 10.1016/j.earlhumdev.2016.01.013. Epub 2016 Feb 28.

Authors

Simon Eaton¹, Clare M Rees², Nigel J Hall³

Affiliations

¹ UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, UK. Electronic address: s.eaton@ucl.ac.uk.
² UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, UK.
³ Faculty of Medicine, University of Southampton, Southampton, UK.

PMID: 26923373
DOI: 10.1016/j.earlhumdev.2016.01.013

Abstract

Despite decades of research on necrotizing enterocolitis, we still do not fully understand the pathogenesis of the disease, how to prevent or how to treat the disease. However, as a result of recent significant advances in the microbiology, molecular biology, and cell biology of the intestine of premature infants and infants with necrotizing enterocolitis, there is some hope that research into this devastating disease will yield some important translation into improved outcomes.

Keywords: TLR4; inflammation; intestinal microbiota; necrotizing enterocolitis; premature infants; surgery.

Publication types

Review

MeSH terms

Enterocolitis, Necrotizing / diagnosis
Enterocolitis, Necrotizing / etiology*
Enterocolitis, Necrotizing / therapy
Humans
Infant Nutritional Physiological Phenomena
Infant, Newborn
Intestinal Mucosa / immunology
Intestinal Mucosa / microbiology
Intestinal Mucosa / pathology
Microbiota
Toll-Like Receptor 4 / genetics
Toll-Like Receptor 4 / metabolism

Substances

Toll-Like Receptor 4