Current research in necrotizing enterocolitis

Early Hum Dev. 2016 Jun;97:33-9. doi: 10.1016/j.earlhumdev.2016.01.013. Epub 2016 Feb 28.


Despite decades of research on necrotizing enterocolitis, we still do not fully understand the pathogenesis of the disease, how to prevent or how to treat the disease. However, as a result of recent significant advances in the microbiology, molecular biology, and cell biology of the intestine of premature infants and infants with necrotizing enterocolitis, there is some hope that research into this devastating disease will yield some important translation into improved outcomes.

Keywords: TLR4; inflammation; intestinal microbiota; necrotizing enterocolitis; premature infants; surgery.

Publication types

  • Review

MeSH terms

  • Enterocolitis, Necrotizing / diagnosis
  • Enterocolitis, Necrotizing / etiology*
  • Enterocolitis, Necrotizing / therapy
  • Humans
  • Infant Nutritional Physiological Phenomena
  • Infant, Newborn
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / microbiology
  • Intestinal Mucosa / pathology
  • Microbiota
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / metabolism


  • Toll-Like Receptor 4