Development and evaluation of an online three-level proton vs photon decision support prototype for head and neck cancer - Comparison of dose, toxicity and cost-effectiveness

Qing Cheng; Erik Roelofs; Bram L T Ramaekers; Daniëlle Eekers; Johan van Soest; Tim Lustberg; Tim Hendriks; Frank Hoebers; Hans Paul van der Laan; Erik W Korevaar; Andre Dekker; Johannes A Langendijk; Philippe Lambin

doi:10.1016/j.radonc.2015.12.029

Development and evaluation of an online three-level proton vs photon decision support prototype for head and neck cancer - Comparison of dose, toxicity and cost-effectiveness

Radiother Oncol. 2016 Feb;118(2):281-5. doi: 10.1016/j.radonc.2015.12.029. Epub 2016 Feb 26.

Affiliations

¹ Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands.
² Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Center, The Netherlands.
³ Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
⁴ Department of Radiation Oncology (MAASTRO Clinic), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands. Electronic address: philippe.lambin@maastro.nl.

PMID: 26924342
DOI: 10.1016/j.radonc.2015.12.029

Abstract

To quantitatively assess the effectiveness of proton therapy for individual patients, we developed a prototype for an online platform for proton decision support (PRODECIS) comparing photon and proton treatments on dose metric, toxicity and cost-effectiveness levels. An evaluation was performed with 23 head and neck cancer datasets.

Keywords: Cost-effectiveness estimation; Decision support system; Mean dose extraction; Proton therapy; Quantitative comparison; Toxicity prediction.

Publication types

Comparative Study
Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Cost-Benefit Analysis / economics*
Decision Support Techniques*
Evaluation Studies as Topic
Head and Neck Neoplasms / economics
Head and Neck Neoplasms / radiotherapy*
Humans
Photons / therapeutic use*
Proton Therapy / economics*
Proton Therapy / methods*
Radiotherapy Dosage