Ocular myasthenia gravis after D-penicillamine administration

Br J Ophthalmol. 1989 Dec;73(12):1015-8. doi: 10.1136/bjo.73.12.1015.


A 68-year-old black woman who was put on D-penicillamine therapy (250-500 mg per day, total dose 15 g) for rheumatoid arthritis developed ocular myasthenia gravis. Two weeks after she discontinued D-penicillamine her signs and symptoms cleared with no other treatment. Review of previous cases and possible immunological mechanisms are discussed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Blepharoptosis / chemically induced*
  • Diplopia / chemically induced*
  • Female
  • Humans
  • Myasthenia Gravis / chemically induced*
  • Penicillamine / adverse effects*


  • Penicillamine