Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood

Huan Zhao; Qinghua Peng; Zhuzhen Han; Li Yang; Zhengtao Wang

doi:10.3390/molecules21030281

Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood

Molecules. 2016 Feb 27;21(3):281. doi: 10.3390/molecules21030281.

Authors

Huan Zhao¹, Qinghua Peng², Zhuzhen Han³, Li Yang^{4

5}, Zhengtao Wang^{6

7}

Affiliations

¹ The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China. 12248573@163.com.
² The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China. 15001972558@163.com.
³ The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China. hltang@126.com.
⁴ The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China. yangli7951@hotmail.com.
⁵ Shanghai R & D Centre for Standardization of Chinese Medicines, Shanghai 201203, China. yangli7951@hotmail.com.
⁶ The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China. ztwang@shutcm.edu.cn.
⁷ Shanghai R & D Centre for Standardization of Chinese Medicines, Shanghai 201203, China. ztwang@shutcm.edu.cn.

Abstract

Three new sesquiterpenoids (1-3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5-7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC50 value of 8.1 μM.

Keywords: Chinese eaglewood; X-ray diffraction; anti-inflammatory activity; sesquiterpenoid derivative; sesquiterpenoids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification
Lipopolysaccharides / adverse effects
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitrogen Oxides / metabolism
RAW 264.7 Cells
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology*
Thymelaeaceae / chemistry*
X-Ray Diffraction

Substances

Anti-Inflammatory Agents
Drugs, Chinese Herbal
Lipopolysaccharides
Nitrogen Oxides
Sesquiterpenes