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. 2015;5(4):207-13.
doi: 10.15171/bi.2015.30. Epub 2015 Dec 28.

Recent Advances in Immunosensor for Narcotic Drug Detection

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Free PMC article

Recent Advances in Immunosensor for Narcotic Drug Detection

Sonu Gandhi et al. Bioimpacts. .
Free PMC article

Abstract

Introduction: Immunosensor for illicit drugs have gained immense interest and have found several applications for drug abuse monitoring. This technology has offered a low cost detection of narcotics; thereby, providing a confirmatory platform to compliment the existing analytical methods.

Methods: In this minireview, we define the basic concept of transducer for immunosensor development that utilizes antibodies and low molecular mass hapten (opiate) molecules.

Results: This article emphasizes on recent advances in immunoanalytical techniques for monitoring of opiate drugs. Our results demonstrate that high quality antibodies can be used for immunosensor development against target analyte with greater sensitivity, specificity and precision than other available analytical methods.

Conclusion: In this review we highlight the fundamentals of different transducer technologies and its applications for immunosensor development currently being developed in our laboratory using rapid screening via immunochromatographic kit, label free optical detection via enzyme, fluorescence, gold nanoparticles and carbon nanotubes based immunosensing for sensitive and specific monitoring of opiates.

Keywords: Aptasensor; Immunoanalytical techniques; Immunosensor; Narcotic drugs; Transducer.

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References

    1. Esseiva P, Dujourdy L, Anglada F, Taroni F, Margot P. A methodology for illicit heroin seizures comparison in a drug intelligence perspective using large database. Forensic Sci Int. 2003;132:139–152. doi: 10.1016/S0379-0738(03)00010-0. - DOI - PubMed
    1. Dujourdy L, Barbati G, Taroni F, Gueniat O, Esseiva P, Anglada F. et al. Evaluation of links in heroin seizures. Forensic Sci Int. 2003;131:171–183. doi: 10.1016/S0379-0738(02)00432-2. - DOI - PubMed
    1. Contreras MT, Hernandez AF, Gonzalez M, Gonzalez S, Ventura R, Pla A. et al. Application of pericardial fluid to the analysis of morphine (heroin) and cocaine in forensic toxicology. Forensic Sci Int. 2006;164:168–171. doi: 10.1016/j.forsciint.2005.12.030. - DOI - PubMed
    1. Hutchinson MR, Somogyi AA. Diacetylmorphine degradation to 6 monoacetylmorphine and morphine in cell culture: implications for in vitro studies. Eur J Pharmacol. 2002;453:27–32. doi: 10.1016/S0014-2999(02)02365-8. - DOI - PubMed
    1. Baker PB, Gough TA. The separation and quantitation of the narcotic components of illicit heroin using reversed phase high performance liquid chromatography. J Chromat Sci. 1981;19:483–489. doi: 10.1093/chromsci/19.10.483. - DOI - PubMed

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