Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity

PLoS One. 2016 Mar 1;11(3):e0150226. doi: 10.1371/journal.pone.0150226. eCollection 2016.


Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Movement / drug effects*
  • Cell Movement / physiology
  • Chondroitin Sulfate Proteoglycans / pharmacology*
  • HT29 Cells
  • Humans
  • Keratan Sulfate / pharmacology*
  • Lumican
  • Matrix Metalloproteinase 14 / metabolism*
  • Melanoma / metabolism*
  • Melanoma / pathology
  • Snail Family Transcription Factors
  • Transcription Factors / metabolism*


  • Chondroitin Sulfate Proteoglycans
  • LUM protein, human
  • Lumican
  • Snail Family Transcription Factors
  • Transcription Factors
  • Keratan Sulfate
  • Matrix Metalloproteinase 14