A short-term zinc-deficient diet decreases bone formation through down-regulated BMP2 in rat bone

Biosci Biotechnol Biochem. 2016 Jul;80(7):1433-5. doi: 10.1080/09168451.2016.1153955. Epub 2016 Mar 2.

Abstract

We investigated the effects of a short-term dietary zinc deficiency on bone metabolism. Zinc deficiency increased the mRNA expression of zinc uptake transporters such as Zip1, Zip13, and Zip14 in bone. However, zinc deficiency might not maintain zinc storage in bone, resulting in a decrease in bone formation through downregulation of the expression levels of osteoblastogenesis-related genes.

Keywords: bone formation; short-term zinc deficiency; zinc transporter.

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 2 / antagonists & inhibitors
  • Bone Morphogenetic Protein 2 / genetics*
  • Bone Morphogenetic Protein 2 / metabolism
  • Cation Transport Proteins / agonists
  • Cation Transport Proteins / genetics
  • Cation Transport Proteins / metabolism
  • Collagen Type I / blood
  • Collagen Type I / genetics
  • Core Binding Factor Alpha 1 Subunit / genetics
  • Core Binding Factor Alpha 1 Subunit / metabolism
  • Diet
  • Femur / metabolism*
  • Gene Expression Regulation
  • Male
  • Osteoblasts / metabolism*
  • Osteocalcin / blood
  • Osteocalcin / genetics
  • Osteogenesis / genetics*
  • Peptides / blood
  • Peptides / genetics
  • Rats
  • Rats, Wistar
  • Signal Transduction
  • Sp7 Transcription Factor
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Zinc / deficiency*

Substances

  • Bmp2 protein, mouse
  • Bone Morphogenetic Protein 2
  • Cation Transport Proteins
  • Collagen Type I
  • Core Binding Factor Alpha 1 Subunit
  • Peptides
  • Runx2 protein, mouse
  • SLC39A14 protein, mouse
  • Slc39a1 protein, mouse
  • Slc39a13 protein, mouse
  • Sp7 Transcription Factor
  • Sp7 protein, mouse
  • Transcription Factors
  • collagen type I trimeric cross-linked peptide
  • Osteocalcin
  • Zinc