A noninvasive high frequency oscillation ventilator: Achieved by utilizing a blower and a valve

Rev Sci Instrum. 2016 Feb;87(2):025113. doi: 10.1063/1.4942048.


After the High Frequency Oscillatory Ventilation (HFOV) has been applied in the invasive ventilator, the new technique of noninvasive High Frequency Oscillatory Ventilation (nHFOV) which does not require opening the patient's airway has attracted much attention from the field. This paper proposes the design of an experimental positive pressure-controlled nHFOV ventilator which utilizes a blower and a special valve and has three ventilation modes: spontaneous controlled ventilation combining HFOV, time-cycled ventilation combining HFOV (T-HFOV), and continuous positive airway pressure ventilation combining HFOV. Experiments on respiratory model are conducted and demonstrated the feasibility of using nHFOV through the control of fan and valve. The experimental ventilator is able to produce an air flow with small tidal volume (VT) and a large minute ventilation volume (MV) using regular breath tubes and nasal mask (e.g., under T-HFOV mode, with a maximum tidal volume of 100 ml, the minute ventilation volume reached 14,400 ml). In the process of transmission, there is only a minor loss of oscillation pressure. (Under experimental condition and with an oscillation frequency of 2-10 Hz, peak pressure loss was around 0%-50% when it reaches the mask.).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • High-Frequency Ventilation / instrumentation*
  • High-Frequency Ventilation / methods*
  • Humans
  • Models, Biological*
  • Respiratory Mechanics*
  • Sheep
  • Ventilators, Mechanical*