Skeletal Muscle Hypertrophy with Concurrent Exercise Training: Contrary Evidence for an Interference Effect

Sports Med. 2016 Aug;46(8):1029-39. doi: 10.1007/s40279-016-0496-y.


Over the last 30+ years, it has become axiomatic that performing aerobic exercise within the same training program as resistance exercise (termed concurrent exercise training) interferes with the hypertrophic adaptations associated with resistance exercise training. However, a close examination of the literature reveals that the interference effect of concurrent exercise training on muscle growth in humans is not as compelling as previously thought. Moreover, recent studies show that, under certain conditions, concurrent exercise may augment resistance exercise-induced hypertrophy in healthy human skeletal muscle. The purpose of this article is to outline the contrary evidence for an acute and chronic interference effect of concurrent exercise on skeletal muscle growth in humans and provide practical literature-based recommendations for maximizing hypertrophy when training concurrently.

Publication types

  • Letter
  • Review

MeSH terms

  • Adaptation, Physiological
  • Humans
  • Muscle Strength / physiology
  • Muscle, Skeletal / anatomy & histology*
  • Muscle, Skeletal / physiology*
  • Physical Conditioning, Human / methods*
  • Physical Endurance / physiology
  • Resistance Training*
  • Sports Nutritional Physiological Phenomena
  • Time Factors