Characterization of nineteen antimony(III) complexes as potent inhibitors of photosystem II, carbonic anhydrase, and glutathione reductase

Mehmet Sayım Karacan; Margarita V Rodionova; Turgay Tunç; Kübra Begüm Venedik; Serhat Mamaş; Alexandr V Shitov; Sergei K Zharmukhamedov; Vyacheslav V Klimov; Nurcan Karacan; Suleyman I Allakhverdiev

doi:10.1007/s11120-016-0236-z

Characterization of nineteen antimony(III) complexes as potent inhibitors of photosystem II, carbonic anhydrase, and glutathione reductase

Photosynth Res. 2016 Dec;130(1-3):167-182. doi: 10.1007/s11120-016-0236-z. Epub 2016 Mar 1.

Affiliations

¹ Department of Chemistry, Science Faculty, Gazi University, Teknikokullar, Ankara, Turkey. mkaracan@gazi.edu.tr.
² Controlled Photobiosynthesis Laboratory, Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya Street 35, Moscow, Russia, 127276.
³ Department of Chemistry and Process Engineering, Engineering and Architecture Faculty, Ahi Evran University, Kırşehir, Turkey.
⁴ Department of Chemistry, Science Faculty, Gazi University, Teknikokullar, Ankara, Turkey.
⁵ Institute of Basic Biological Problems, Russian Academy of Sciences, Institutskaya Street 2, Pushchino, Moscow Region, Russia, 142290.
⁶ Department of Chemistry, Science Faculty, Gazi University, Teknikokullar, Ankara, Turkey. nkaracan@gazi.edu.tr.
⁷ Controlled Photobiosynthesis Laboratory, Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya Street 35, Moscow, Russia, 127276. suleyman.allakhverdiev@gmail.com.
⁸ Institute of Basic Biological Problems, Russian Academy of Sciences, Institutskaya Street 2, Pushchino, Moscow Region, Russia, 142290. suleyman.allakhverdiev@gmail.com.
⁹ Department of Plant Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, Leninskie Gory 1-12, Moscow, Russia, 119991. suleyman.allakhverdiev@gmail.com.

PMID: 26932934
DOI: 10.1007/s11120-016-0236-z

Abstract

Nineteen antimony(III) complexes were obtained and examined as possible herbicides. Six of these were synthesized for the first time, and their structures were identified using elemental analyses, ¹H-NMR, ¹³C-NMR, FTIR, LCMS, magnetic susceptibility, and conductivity measurement techniques. For the nineteen examined antimony(III) complexes their most-stable forms were determined by DFT/B3LYP/LanL2DZ calculation method. These compounds were examined for effects on photosynthetic electron transfer and carbonic anhydrase activity of photosystem II, and glutathione reductase from chloroplast as well were investigated. Our results indicated that all antimony(III) complexes inhibited glutathione reductase activity of chloroplast. A number of these also exhibited good inhibitory efficiency of the photosynthetic and carbonic anhydrase activity of Photosystem II.

Keywords: Antimony(III) complexes; Carbonic anhydrase; Glutathione reductase; Inhibitors; Photosystem II (PSII).

MeSH terms

Antimony / chemistry
Antimony / pharmacology*
Carbonic Anhydrase Inhibitors / pharmacology*
Chloroplasts / drug effects
Glutathione Reductase / antagonists & inhibitors*
Herbicides / pharmacology
Magnetic Resonance Spectroscopy
Photosystem II Protein Complex / drug effects*
Structure-Activity Relationship

Substances

Carbonic Anhydrase Inhibitors
Herbicides
Photosystem II Protein Complex
Antimony
Glutathione Reductase