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Elevated C-Reactive Protein Is Associated With Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)


Elevated C-Reactive Protein Is Associated With Cognitive Decline in Outpatients of a General Hospital: The Project in Sado for Total Health (PROST)

Yumi Watanabe et al. Dement Geriatr Cogn Dis Extra.


Background/aims: We aimed to determine whether the concentration of serum C-reactive protein (CRP) is associated with cognitive function in an adult Japanese population.

Methods: Participants of this cross-sectional study were from a subgroup of the Project in Sado for Total Health (PROST; n = 454; mean age, 70.5 years). The cognitive state was evaluated using the Mini-Mental State Examination (MMSE), and those with an MMSE score <24 were considered 'cognitively declined'. Concentrations of serum high-sensitivity CRP were measured. Multiple logistic regression analysis was used to calculate odds ratios (ORs) for cognitive decline, adjusting for the covariates of age, sex, BMI, disease history, and APOE allele.

Results: Of the 454 participants, 94 (20.7%) were cognitively declined. Relative to the lowest (first) quartile of CRP concentration, adjusted ORs were 1.29 (95% CI 0.61-2.75) for the second, 1.78 (95% CI 0.82-3.86) for the third, and 3.05 (95% CI 1.45-6.42) for the highest (fourth) quartiles (p for trend = 0.018). When data were stratified by sex, the association between CRP concentration and cognitive decline was observed only in women.

Conclusion: Our findings suggest an association between higher CRP concentration and lower cognitive function. Chronic inflammation may affect cognitive function in adults, in particular women.

Keywords: C-reactive protein; Cognition in outpatients; Cross-sectional studies; Elderly Japanese population; Epidemiology.


Fig. 1
Fig. 1
The age distribution of study participants. The value above the bar shows the number of subjects in each bin.

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    1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer's Disease International Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366:2112–2117. - PMC - PubMed
    1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013;9:63–75. e2. - PubMed
    1. Alzheimer's Association 2013 Alzheimer's disease facts and figures. Alzheimers Dement. 2013;9:208–245. - PubMed
    1. United Nations, Department of Economic and Social Affairs, Population Division World Population Prospects: The 2015 Revision, Key Findings and Advance Tables. New York, United Nations, 2015
    1. Jack CR, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010;9:119–128. - PMC - PubMed